(NewsNation) — Iran and Israel traded missile fire overnight and into Wednesday, marking the sixth day of attacks between the countries as the United States seems poised for possible intervention.

As the U.S. shifted warplanes and ships to the Middle East on Tuesday, Trump touted control of Iran’s skies and called for its “unconditional surrender.”

On Wednesday, Iran’s Supreme Leader Ayatollah Ali Khamenei rejected that demand and voiced suspicion of U.S. involvement in “the malicious move carried out by the Zionist regime.”

“What should the Iranian nation surrender to? We will never surrender in response to the attacks of anyone,” Khamenei said on social media. “This is the logic of the Iranian nation. This is the spirit of the Iranian nation.”

In a separate post, Khamenei warned: “The US entering in this matter [war] is 100% to its own detriment. The damage it will suffer will be far greater than any harm that Iran may encounter.”

Iran’s foreign ministry on Wednesday also said direct involvement from the U.S. could lead to “all-out war.”

Bipartisan pushback to potential US involvement in Israel-Iran conflict

One of Trump’s most loyal backers spoke out Wednesday against U.S. intervention in the conflict.

“Americans want cheap gas, groceries, bills, and housing. They want affordable insurance, safe communities, and good education for their children. They want a government that works on these issues,” Greene’s post reads. “Considering Americans pay for the entire government and government salaries with their hard earned tax dollars, this is where our focus should be. Not going into another foreign war.”

Former Arkansas governor Asa Hutchinson told NewsNation on Wednesday that Trump views the situation as opportunity to take out Iran’s nuclear threat, though some of his threats have divided the GOP.

“I come down that Iran is a threat both to Israel and to the United States, and we need to look at our best option now to make sure they don’t develop that nuclear capability,” Hutchinson said on “Morning in America.”

“This is not our war. But if it were, Congress must decide such matters according to our Constitution. I’m introducing a bipartisan War Powers Resolution tomorrow to prohibit our involvement,” Massie said. “I invite all members of Congress to cosponsor this resolution.”

Israel, Iran trade attacks as casualties mount

Israel sent a barrage of attacks on Wednesday morning, according to a post from the Israeli Air Force on the social platform X: “The Air Force identified and attacked five Iranian AH-1 combat helicopters at a military base in the Kermanshah area. These helicopters were intended to target Air Force aircraft operating in Iranian airspace.”

NewsNation crews in Tel Aviv observed an active night in the Middle East. Within the span of one hour, Iran fired two separate missile salvos, causing millions to take shelter.

Missiles fired from Iran are pictured in the night sky over Jerusalem on June 14, 2025. Israel and Iran exchanged fire on June 14, a day after Israel unleashed an unprecedented aerial bombing campaign that Iran said hit its nuclear facilities, “martyred” top commanders and killed dozens of civilians (Photo by Menahem Kahana / GETTY-AFP)
Smoke billows from an explosion at the Islamic Republic of Iran Broadcasting building in Tehran on June 16, 2025. The IRIB building was struck in an Israeli attack on June 16, cutting live coverage immediately. The blast occurred as the presenter was live on TV lambasting Israel before she was seen leaving the live broadcast, Iranian media reported, sharing a video of the incident. (Photo by Getty-AFP)
Israeli rescuers search through the rubble at the site of an overnight Iranian missile strike in Bat Yam on June 15, 2025. Israeli Prime Minister Benjamin Netanyahu said that Iran would pay “a very heavy price” for killing Israeli civilians, during a June 15 visit to the site of a missile strike on a residential building near Tel Aviv, as the two foes kept up intense fighting. (Photo by Menahem Kahana /Getty-AFP)

Though Iran’s attacks remain frequent, the missiles used are growing smaller. The Israelis contend this is because their Air Force is degrading Iran’s capabilities, pushing their ballistic launch sites out of the west towards central Iran.

Iranian leadership has rejected that premise, saying their capabilities have not been degraded but that they are holding back. Officials warned that if Israel does not relent, Iran will up its strikes from a level of deterrence to what they describe as “punitive” to major population centers.

Iranian Army Commander-in-Chief Abdolrahim Mousavi issued a warning to Israeli residents to evacuate Haifa and Tel Aviv “for their own safety and not to become victims of Netanyahu’s barbaric actions.”

Iran has fired approximately 400 missiles and hundreds of drones in retaliatory strikes that have killed at least 24 people in Israel and wounded hundreds.

Washington-based Iranian human rights group said at least 585 people, including 239 civilians, have been killed and more than 1,300 wounded by Israeli attacks.

The Associated Press contributed to this report.